Aflaquinolones A-G: Secondary metabolites from marine and fungicolous isolates of Aspergillus spp.

Seven new compds. (aflaquinolones A-G; 1-7) contg. dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources. Two of these metabolites (1 and 2) were obtained from a Hawaiian fungicolous isolate of Aspergillus sp. (section Flavipedes; MYC-2048 = NRRL 58570), while the others were obtained from a marine Aspergillus isolate (SF-5044) collected in Korea. The structures of these compds. were detd. mainly by anal. of NMR and MS data. Relative and abs. configurations were assigned on the basis of NOESY data and 1H NMR J-values, comparison of calcd. and exptl. ECD spectra, and anal. of a Mosher's ester deriv. of 2. Several known compds., including alantrypinone, aspochalasins I and J, Me 3,4,5-trimethoxy-2((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate, and trans-dehydrocurvularin were also encountered in the ext. of the Hawaiian isolate. [on SciFinder(R)]