Hymenopsins A and B and a macrophorin analog from a fungicolous Hymenopsis sp.

Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analog, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638). The structures and relative configurations of these compds. were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallog. anal. The abs. configuration of 2 was proposed on the basis of CD anal. using both empirical and computational methods. Compds. 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compd. 3 was also active against Aspergillus flavus and Fusarium verticillioides. [on SciFinder(R)]